Pharmacological studies on expectorants.
- 1 January 1977
- journal article
- research article
- Published by Japanese Pharmacological Society in Folia Pharmacologica Japonica
- Vol. 73 (5) , 605-624
- https://doi.org/10.1254/fpj.73.605
Abstract
Perry and Boyd''s method described in 1941 appears to be the most suitable for evaluating the efficacy of expectorants. In this method, chanes in volume of respiratory tract fluid (RTF) collected by postural drainage from animals breathing air kept at a constant temperature and humidity are used as criteria. An air conditioning apparatus and tracheal cannula were re-designed and basic experimental conditions essential for quantitative collection of RTF [in rabbits] were studied. Using this method, the effects of drugs on the volume of respiratory tract fluid (VRTF) were determined. Bromhexine and emetine as expectorants increased VRTF, and the former showed far more remarkable effects. Codeine and dextromethorphan as antitussives, isoproterenol, clorprenaline and C-78 [1-(O-chlorophenyl)-2-tert butylaminoethanol hydrochloride] as bronchodilators decreased VTRF. Fominoben and eprazinone as antitussives increased VRTF. The method is applicable for evaluating not only the efficacy of expectorants which increase VRTF but also that of other drugs which decrease VRTF.This publication has 0 references indexed in Scilit: