Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen?q13

1 February 1988

journal article
research article
Published by Springer Nature in Immunogenetics

Vol. 27 (2) , 91-95
https://doi.org/10.1007/bf00351081

Abstract

A cDNA clone has recently been isolated that encodes a protein expressed only in the intermediate and late stages of T-cell differentiation, termed MAL. The polypeptide deduced from the MAL cDNA sequence contains four potential transmembrane domains. We have used a panel of 28 human × rodent hybrid cell lines to assign the MAL gene to the proximal long arm of human chromosome 2, region cen→q13. The significance of the MAL map position and its relationship with other genes on chromosome 2 are discussed.

Keywords

This publication has 35 references indexed in Scilit:

Detection of specific sequences among DNA fragments separated by gel electrophoresis
Published by Elsevier ,2006
Translocation (2;3) in hematologic malignancies
Cancer Genetics and Cytogenetics, 1986
Multiple Mechanisms of Protein Insertion into and Across Membranes
Science, 1985
Sequence and Structure of a Human Glucose Transporter
Science, 1985
Locus of the α-Chain of the T-Cell Receptor Is Split by Chromosome Translocation in T-Cell Leukemias
Science, 1985
Genes for β Chain of Human T-Cell Antigen Receptor Map to Regions of Chromosomal Rearrangement in T Cells
Science, 1985
Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.
The Journal of Experimental Medicine, 1985
Primary structure of human T-cell receptor α-chain
Nature, 1984
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I
Journal of Molecular Biology, 1977
Regional localization of the human genes for malate dehydrogenase-1 and isocitrate dehydrogenase-1 on chromosome 2 by interspecific hybridization using human cells with the balanced reciprocal translocation t(1;2)(q32;q13)
Cytogenetic and Genome Research, 1975