High resolution mass spectrometry. Part X. Loss of water from the molecular ions of aromatic amides

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Abstract
Thermal loss of water by aromatic amides in the mass spectrometer is well known; it is now shown that when the amide group is flanked by both a methyl and a nitro-group elimination of water occurs by an electron-impact process. In view of the results of deuterium-labelling studies a mechanism is proposed for this loss in the case of 1-methyl-4-nitroimidazole-5-carboxamide. It is further shown that the resulting ion does not have the nitrile structure.

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