Polyps and Pigment in the Peutz-Jeghers Syndrome

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Abstract
THE clinical condition described by Peutz,1 of Holland, in 1921 was characterized by him as a remarkable situation of familial polyposis of the mucosa of the small intestine with unusual skin and mucosal pigmentation.Generally, the pattern consists of areas of melanosis in the facial and digital skin as well as buccal and other mucosal sites associated with polyps of the small intestines. The majority of the patients are of dark complexion with a personal and family history of discrete blue, black or dark-brown pigmentation, or intestinal disturbances, or both.2 As a rule there is a fairly long story of . . .