Chemical Analysis of Massive Crystalluria Following Primidone Overdose
- 1 November 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 58 (5) , 583-589
- https://doi.org/10.1093/ajcp/58.5.583
Abstract
A 43-year-old woman was hospitalized with a 36-hr. history of stupor and massive crystalluria following an apparent suicide attempt. Toxicologic studies revealed phenobarbital and primidone in both blood and urine. Col-lection, purification, and chemical analysis of the urinary crystals are described. Microscopic examination, melting-point studies, infrared and ultra-violet spectroscopy, and thin-layer and gas–liquid chromatography identified the crystals as primidone. The clinical utility of crystalluria in the diagnosis of primidone overdosage is emphasized.Keywords
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