Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes
- 1 February 1997
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 27 (4) , 533-541
- https://doi.org/10.1080/00397919708003323
Abstract
The reaction rate of Knoevenagel condensation can be dramatically enhanced by irradiating the reaction mixture containing ethyl cyanoacetate, an aldehyde, P2O5, piperidine, and chlorobenzene with a commercial microwave oven. A number of Knoevenagel condensation products were prepared in good yields in very short reaction times (2-15min) under the microwave irradiation.Keywords
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