HISTAMINE AS THE POSSIBLE CHEMICAL MEDIATOR FOR CUTANEOUS PAIN

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Abstract
Painful sensations may be produced by the injn. of histamine, at concns. as low as 10-18, into the superficial layers of the cutis. These findings are taken to indicate specificity of histamine in production of cutaneous pain and substantiate the postulate that a histamine-like substance acts as a physiologic mediator of pain. Acetylcholine and adeno-sine apparently do not augment the cutaneous pain-producing action of histamine. The fact that production of itching requires a higher concn. of histamine than that necessary for pain indicates that itching is not a "subthreshold" pain. The least perceptible manifestations of pain are "prickling," "stinging" or "tingling.".

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