The genetics of chronic obstructive pulmonary disease
Open Access
- 11 January 2001
- journal article
- review article
- Published by Springer Nature in Respiratory Research
- Vol. 2 (1) , 20-26
- https://doi.org/10.1186/rr34
Abstract
Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.Keywords
This publication has 68 references indexed in Scilit:
- Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC NorfolkEuropean Respiratory Journal, 2000
- Increased risk of obstructive pulmonary disease in tunnel workersThorax, 2000
- Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1Thorax, 2000
- Decline in FEV1 related to smoking status in individuals with severe alpha1-antitrypsin deficiency (PiZZ)European Respiratory Journal, 1999
- Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysemaThe Lancet, 1997
- The molecular basis of α1-antichymotrypsin deficiency in a heterozygote with liver and lung diseaseJournal of Hepatology, 1993
- Decline of lung function and development of chronic airflow limitation: a longitudinal study of non-smokers and smokers in Busselton, Western Australia.Thorax, 1990
- Twelve Years Spirometric Changes Among Paris Area WorkersInternational Journal of Epidemiology, 1979
- The natural history of chronic airflow obstruction.BMJ, 1977
- THE URBAN FACTOR IN CHRONIC BRONCHITISThe Lancet, 1965