Synthetic Studies on a Cyclic Hexadepsipeptide GE3: Stereoselective Construction of the Acyl Side Chain Segment
- 1 January 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (04) , 0613-0615
- https://doi.org/10.1055/s-2002-22724
Abstract
Stereoselective synthesis of the acyl side chain segment 2 of GE3 (1), a potent inhibitor of cell progression of the cell cycle from the G1 to S phase, has been achieved by using Sharpless’ asymmetric dihydroxylation and Evans’ and Paterson’s stereoselective aldol methodologies.Keywords
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