Mucin‐type O‐glycans in human colon and breast cancer: glycodynamics and functions
Top Cited Papers
Open Access
- 1 June 2006
- journal article
- review article
- Published by Springer Nature in EMBO Reports
- Vol. 7 (6) , 599-604
- https://doi.org/10.1038/sj.embor.7400705
Abstract
The glycoproteins of tumour cells are often abnormal, both in structure and in quantity. In particular, the mucin‐type O ‐glycans have several cancer‐associated structures, including the T and Tn antigens, and certain Lewis antigens. These structural changes can alter the function of the cell, and its antigenic and adhesive properties, as well as its potential to invade and metastasize. Cancer‐associated mucin antigens can be exploited in diagnosis and prognosis, and in the development of cancer vaccines. The activities and Golgi localization of glycosyltransferases are the basis for the glycodynamics of cancer cells, and determine the ranges and amounts of specific O ‐glycans produced. This review focuses on the glycosyltransferases of colon and breast cancer cells that determine the pathways of mucin‐type O ‐glycosylation, and the proposed functional and pathological consequences of altered O ‐glycans.Keywords
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