QUANTITATIVE CHARACTERIZATION OF SUBCOMPONENTS IN RAT HEMOGLOBIN

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Abstract
Relative existence ratios of the 5 hemoglobin subcomponents were determined by combined use of column chromato-graphic and electrophoretic techniques in 5 rats of a Sprague-Dawley strain. The values for each subcomponent were not only constant in the same individuals with the lapse of 5 months, but also show little individual variation except 1 rat. The values were scarcely altered by artificial induction of severe anemic state. In 1 rat the anodal 3rd subcomponent was in a significantly depressed level as compared with those in other 4 rats. All the 5 subcomponents were shown not to be the secondary products of aggregation or disaggregation from normal tetrameric hemoglobin molecule(s). The above results suggest that the 5 subcomponents may represent 5 inherent molecular forms of hemoglobin.

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