Leucopénie chronique par ‘auto-anticorps’

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Abstract
A case of chronic leukopenia is described due to a factor in the serum. This factor was contained in the beta 2- and gamma-globulins and had the characteristics of an antileukocytic antibody. The peculiar character of this factor was detd. by these observations: (1) the intraven. injn. of 3-3.5 mol of serum per kg. body weight caused death in rabbits by leukocytic emboli in lungs and kidneys; (2) absorption tests showed that the addition of normal leukocytes inhibited the action of the serum; (3) after absorption the beta 2- and gamma-globulin fractions in the serum of the patient were diminished; (4) the leukopenic factor remained even after splenectomy and after clinical cure of the patient.