THE SPECIFICITY OF PANCREATIC LIPASE: ITS APPEARANCE IN THE BLOOD AFTER PANCREATIC INJURY

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Abstract
Following obstruction of the pancreas in [10] dogs an olive oil hydrolyzing lipase appeared in the blood in large amts.; there wag no significant uniform change in esterase as measured by hydrolysis of ethyl butyrate or tributyrin. This is interpreted as evidence of the specificity of lipase; it is suggested that the term "lipase" be reserved for the enzyme (or enzymes) capable of splitting true fats and oils, and that the term esterase be used for the enzyme (or enzymes) acting upon the simple esters. Lipase (hydrolyzing olive oil) was found in significant amts. only in pancreas, intestinal mucosa, liver, and spleen. All tissues studied contained an esterase. A study of the activity of pancreatic and liver extracts and blood serum on 21 esters gave no evidence of specificity other than that indicated by the absence of activity toward olive oil in certain tissues and its presence in others.

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