Electron Microscopic Studies on Civatte Body in Riehl's Melanosis

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Abstract
Civatte bodies were investigated with light and EM patients with Riehl''s melanosis. They were present in the lower part of the epidermis and/or in the upper dermis of the lesions of all patients. In the epidermis they were composed of wavily arranged fine filaments and entangled melanosomes, demonsomes and other cell organelles. In the dermis Civatte bodies seemed to transform into net-like or more amorphous masses. Melanosomes, desmosomes and other cell organelles were observed within them, although in small numbers. Dermal components containing collagen fibrils were occasionally seen merged into the rims of Civatte bodies in the dermis. These Civatte bodies appeared to incorporate the adjacent dermal components and further mix with them to transform into amyloid-like filament masses. The amyloid-like filament masses consisted of straight and nonbranching filaments and were observed in the lesions of 4 patients under the EM. They could not be identified as amyloid itself with light microscope because they were negative in the thioflavin T and congo red stainings.

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