Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors
- 22 May 2000
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 10 (9) , 963-966
- https://doi.org/10.1016/s0960-894x(00)00139-6
Abstract
No abstract availableKeywords
This publication has 7 references indexed in Scilit:
- Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsinActa Crystallographica Section D-Biological Crystallography, 1999
- Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor XaJournal of Medicinal Chemistry, 1998
- X-ray Structure of Active Site-inhibited Clotting Factor XaPublished by Elsevier ,1996
- Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombinFEBS Letters, 1995
- Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa InhibitorsJournal of Medicinal Chemistry, 1994
- The coagulation cascade: initiation, maintenance, and regulationBiochemistry, 1991
- CCCXVII.—The formation of 2-substituted benziminazolesJournal of the Chemical Society, 1928