Newborn Infants of Tuberculous Mothers, Further Comment

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Abstract
In their recent article, Avery and Wolfsdorf discussed INH prophylaxis of infants of tuberculous mothers and stated, "The unusual reactions of infants to many pharmacologic agents, with respect to absorption and excretion, have necessitated great care in matters of dosage and indications in infancy." The Committee on Drugs commented, in the same issue, that the pharmacology of INH has not been systematically studied in the newborn infant. We have been studying the characteristics of the hepatic enzyme which catalyzes the acetylation of INH and sulfonamides.

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