CHEMOTACTIC RESPONSE OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES FOLLOWING INVIVO ADMINISTRATION OF SPIRAMYCIN

  • 1 July 1986
    • journal article
    • research article
    • Vol. 17  (3) , 328-330
Abstract
The chemotactic response of polymorphonuclear leukocytes using the agarose method, has been studied in six healthy volunteers, immediately prior and after a 5-day oral administration of spiramycin, 6 million units per day. The influence of spiramycin proved to be small as the directed and spontaneous migration were decreased by 21% and 18% respectively. Despite the fact that spiramycin can penetrate into leukocytes, these results indicate that no clinically relevant alterations of chemotaxis are likely under therapeutic conditions.

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