Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress

Publisher Website
Google Scholar
Abstract
SPECIFIC AIMSAlthough a new gene, termed klotho, is associated with the suppression of several aging phenotypes, little is known about its function in the brain. We investigated the changes in mnemonic function accompanying aging in relation to oxidative stress in klotho mutant mice.PRINCIPAL FINDINGS1. Impaired recognition and associative memory in klotho mutant miceWe evaluated visual recognition memory in a novel object recognition memory task that requires the hippocampus. There were no significant differences in total exploratory time and exploratory preference between wild-type and klotho mutant mice in the training session at the age of 6 or 7 wk (Fig. 1⤻ a), suggesting that the two mice have the same levels of motivation, curiosity, and interest in exploring novel objects. For the retention session, measured 1 and 24 h after the training, one object was replaced by a novel object. A significant difference between wild-type and klotho mutant mice in preference for the novel object was observed duri...
Funding Information
  • Ministry of Education, Culture, Sports, Science and Technology (12210075)