Enhanced secretion of endothelin‐1 by elevated glucose levels from cultured bovine aortic endothelial cells
- 2 July 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 267 (1) , 16-18
- https://doi.org/10.1016/0014-5793(90)80276-o
Abstract
We have investigated the effect of glucose on the release of endothelin‐1‐like immunoreactivity (ET‐l‐LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET‐1‐LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose‐induced ET‐1‐LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET‐1‐LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.Keywords
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