Plasmodium falciparum Parasites Expressing Pregnancy-Specific Variant Surface Antigens Adhere Strongly to the Choriocarcinoma Cell Line BeWo
- 1 May 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (5) , 3035-8
- https://doi.org/10.1128/iai.74.5.3035-3038.2006
Abstract
Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSA PAM ). We report here that VSA PAM -expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSA PAM expression in vitro.Keywords
This publication has 25 references indexed in Scilit:
- Effects of Pregnancy and Intensity of Plasmodium falciparum Transmission on Immunoglobulin G Subclass Responses to Variant Surface AntigensInfection and Immunity, 2005
- The immuno‐epidemiology of pregnancy‐associated Plasmodium falciparum malaria: a variant surface antigen‐specific perspectiveParasite Immunology, 2004
- Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria VaccinesThe Journal of Experimental Medicine, 2004
- Antibodies That Inhibit Plasmodium falciparum Adhesion to Chondroitin Sulfate A Are Associated with Increased Birth Weight and the Gestational Age of NewbornsInfection and Immunity, 2003
- Expression of Variant Surface Antigens by Plasmodium falciparum Parasites in the Peripheral Blood of Clinically Immune Pregnant Women Indicates Ongoing Placental InfectionInfection and Immunity, 2003
- Acquisition and Decay of Antibodies to Pregnancy‐Associated Variant Antigens on the Surface ofPlasmodium falciparum–Infected Erythrocytes That Protect against Placental ParasitemiaThe Journal of Infectious Diseases, 2001
- Plasmodium falciparumIsolates from Infected Pregnant Women and Children Are Associated with Distinct Adhesive and Antigenic PropertiesThe Journal of Infectious Diseases, 1999
- Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human PlacentaScience, 1996
- Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum crossNature, 1990
- Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitroExperimental Cell Research, 1990