Syndecan-1 (CD138) Expression in Acute Myeloblastic Leukemia Cells
Open Access
- 1 January 2003
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Oncologica
- Vol. 42 (1) , 71-74
- https://doi.org/10.1080/0891060310002267
Abstract
Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known; its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.Keywords
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