Nephritogenic Glycoprotein

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Abstract
Rats that were given a single injection in the hind footpads of homologous (watersoluble) renal glycoprotein and Freund's complete (or incomplete) adjuvant developed typical proliferative glomerulonephritis. Proteinuria and morphologic changes of glomerulonephritis continued until death of the animals (the longest period of observation was 12.5 months after injection). The glycoprotein was isolated and purified from rat glomerular basement membrane and had previously been reported from our laboratory to induce nephrotoxic antibody. Immunization of rats with as little as 5 µg of the glycoprotein in Freund's complete adjuvant effectively induced typical proliferative glomerulonephritis. The nephritis could be transferred to previously healthy recipients with the eluate obtained from nephritic kidneys.

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