Studies on peptides. CXXVII. Synthesis of a tripentacontapeptide with epidermal growth factor activity.
- 1 January 1985
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 33 (1) , 184-201
- https://doi.org/10.1248/cpb.33.184
Abstract
The tripentacontapeptide corresponding to the entire linear sequence of epidermal growth factor was synthesized by assembling 15 peptide fragments and one His residue (position 22), followed by deprotection with trifluromethanesulfonic acid-thioanisole in trifluoroacetic acid. The deprotected peptide was subjected to air-oxidation. After purification by ion-exchange chromatography of diethyl aminoethyl cellulose folloed by high performance liquid chromatography, a peptide with powerful anti-gastric activity was obtained.This publication has 2 references indexed in Scilit:
- STUDIES ON PEPTIDES .102. SYNTHESIS OF A HEPTACOSAPEPTIDE AMIDE CORRESPONDING TO THE ENTIRE AMINO-ACID-SEQUENCE OF GASTRIN-RELEASING PEPTIDE1981
- Coordination complexes and catalytic properties of proteins and related substances. 87. Methylation of glucagon, characterization of the sulfonium derivative, and regeneration of the native covalent structureBiochemistry, 1977