USE OF HEPARIN IN SUBACUTE BACTERIAL ENDOCARDITIS

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Abstract
Recent studies from this department1on experimental Streptococcus viridans endocarditis in dogs indicated clearly that the infection persisted because the constant deposition of platelets and fibrin on the vegetation exceeded the rate at which the vegetation implanted on the valve could be sterilized. Further studies on both dogs and human beings suffering from subacute endocarditis of the Streptococcus viridans variety revealed that the blood did not lack the ability to destroy the organism in vitro and that its inability to do so in vivo was due to the fact that the effective agent in the blood, the white blood cell, was unable to reach the focus of infection because of the relative avascularity of the valve leaflets and the dynamics of the blood stream flowing past the vegetations. Because of these facts it was thought possible that the prevention of new fibrin and platelet formation by the use of

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