Aging in man. Linear increase of a novel T cell subset defined by antiganglioside monoclonal antibody 3G5.
Open Access
- 1 May 1987
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 165 (5) , 1436-1441
- https://doi.org/10.1084/jem.165.5.1436
Abstract
A new human T cell subset defined by antineuronal ganglioside mAb 3G5 increases linearly with advancing age in man. The percentage of circulating 3G5+ T cells in 21 normal individuals, quantitated tby cytofluorograph analysis, increases linearly from age 7 (23-30%) to age 84 (58%) (r = 0.85, p < 0.001). The antigen on T cells has the biochemical properties of a ganglioside that migrate between GM1 and GM2 ganglioside markers on TLC. The 3G5 subset represents the first T cell subset that reflects aging in man.This publication has 14 references indexed in Scilit:
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