INCREASE IN AUTOLOGOUS ERYTHROCYTE BINDING BY T-CELLS WITH AGING IN MAN

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (3) , 468-473
Abstract
Studies made of 115 normal subjects of both sexes aged 20-94 yr showed that autologous rosette-forming cell levels in human peripheral blood lymphocytes were related to age and sex. No such relationship was found in response to phytohemagglutinin used with the same subjects. The nature of these autorosettes in human peripheral blood lymphocytes was studied. A significant decrease in autorosette levels was observed from passage through nylon wool at high RBC[red blood cell]/WC [white blood cell] ratios, and at any ratio after E[erythrocyte]-rosette depletion. The results suggesting a T[thymus derived]-cell origin of autorosettes were confirmed by the existence of mixed autologous erythrocyte and sheep red blood cell rosettes.