Use of Polynucleotides with Seminal Antigens to Induce Isoantibodies and Infertility in Rabbits

Publisher Website
Google Scholar
Abstract
Injections of female rabbits with homologous seminal antigens in combination with polyadenylic and polyuridylic acids (0.4-0.5 mg of each per injection) induced antifertility effects and serum titers of specific antibodies. Rabbits immunized with seminal plasma had normal fertility, whereas rabbits immunized with semen and epididymal sperm showed fertilization inhibition after artificial insemination and low embryo and fetal survival after embryo transfer. Immunization with semen induced high serum titers of specific antibodies as determined by passive hemagglutination, sperm agglutination, and sperm immobilization. Epididymal sperm caused moderate hemagglutination titers and high titers of sperm-agglutinating and immobilizing antibodies, whereas seminal plasma induced high hemagglutination titers but low sperm-agglutination titers, and no immobilizing antibody. Sperm-agglutinating and immobilizing titers were highly correlated in rabbits immunized with semen and epididymal sperm.

This publication has 0 references indexed in Scilit: