Studies of Live Attenuated Japanese Encephalitis Vaccine in Swine
Open Access
- 1 January 1968
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 100 (1) , 194-200
- https://doi.org/10.4049/jimmunol.100.1.194
Abstract
Summary: Colostrum-deprived pigs were found to be highly susceptable to Japanese encephalitis (JE) virus even by subcutaneous inoculation. Such animals represent the most suitable host for assaying the virulence of JE virus in swine. When a small dose (10 LD50) of a virulent strain was injected subcutaneously in colostrum-deprived pigs, they showed significant viremia and clinical signs, including nervous symptoms. On the other hand, an attenuated mutant (m) strain of JE virus produced no detectable viremia and no clinical symptoms even when more than 107 TCD50 of the virus was inoculated. The m virus was able to evoke both hemagglutination-inhibiting (HI) and neutralizing antibodies in colostrum-deprived pigs after a single subcutaneous injection. The same antibody responses were also observed after one injection of m virus in young adult pigs with HI antibody titers less than 1:10, and the antibody levels persisted for at least 80 days.This publication has 0 references indexed in Scilit: