Cefazolin concentrations in bone and synovial fluid.
- 1 April 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Bone and Joint Surgery
- Vol. 60 (3) , 359-362
- https://doi.org/10.2106/00004623-197860030-00016
Abstract
A single intravenous dose of one gram of cefazolin was administered prophylactically to forty-eight patients undergoing total joint replacement. The serum half-life of the antibiotic was 1.8 hours, the same value found in normal volunteers. The mean concentration in bone during surgery was 5.7 micrograms per gram of bone. The mean concentration in synovial fluid during surgery was 24.4 micrograms per milliliter of fluid.This publication has 0 references indexed in Scilit: