Progress toward the Synthesis of Sarain A

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Abstract
In this Account we describe our efforts over more than five years to find a synthetic route to saran A (1), a complex marine alkaloid. The basic synthetic plan (Scheme 1) calls for construction of the tricyclic ”core”, annulation of the saturated 13-membered ring, and finally, annulation of the unsaturated 14-membered ring. Synthesis of the core has almost been achieved, and a suitable route has been found to lactam 103, a model for the unsaturated 14-membered ring in sarain A.

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