THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY *

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Abstract
As has been shown in normal non-pregnant humans, the infusion of sodium lactate into 4 normal pregnant subjects resulted in reduced renal clearance of urate (Curate) without significantly affecting renal clearance of creatinine (Ccr). Ten normal and 18 toxemic pregnant patients were studied in the resting, postabsorptive state during the last trimester of pregnancy. Endogenous arterial lactic acid concentrations and simultaneous Curate and Ccr were measured. There was a significant negative correlation between endogenous arterial lactate concentrations and the ratio Curate:Ccr. Is suggested that the increased renal tubular reabsorption of urate (and the associated reduced urate excretion) frequently seen in toxemia of pregnancy are in part due to the effect of elevated arterial concentrations of lactic acid.