Influence of Prostaglandin E1 on Cerebral Mechanisms Involved in the Control of Fluid Balance
- 1 September 1976
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 98 (1) , 85-93
- https://doi.org/10.1111/j.1748-1716.1976.tb10306.x
Abstract
The effects of infusions of PGE1 (30 ng/kg min‐1) into the lateral cerebral ventricle were studied in the conscious, hydrated goat. The infusions caused release of antidiuretic hormone and increased renal sodium excretion. When PGE1 was infused together with hypertonic NaCl these effects became markedly enhanced and the infusion also induced drinking and a rise in the arterial blood pressure. Much weaker effects were obtained by the infusion of the hypertonic NaCl alone. This sodium‐PGE1 interaction is discussed in relation to previously observed, central sodium‐angiotensin II interaction. A more pronounced drinking effect was obtained in response to the intraventricular infusion of PGE1+ angiotensin II, than to the infusion of either substance separately. The PGE1 administered into the lateral cerebral ventricle did not induce any febrile response.This publication has 25 references indexed in Scilit:
- Recovery of ADH Activity in the Urine of Goats under Normal and Stimulated ConditionsActa Physiologica Scandinavica, 1975
- Effects on Fluid Balance of Intraventricular Infusions of Prostaglandin E1Acta Physiologica Scandinavica, 1975
- A cannula system for frequent infusions into the CSF of the cerebral ventricles of the goatPhysiology & Behavior, 1973
- Angiotensin increases microsomal (Na+−K+-ATPase activity in several tissuesBiochimica et Biophysica Acta (BBA) - General Subjects, 1972
- Differences in the Antidiuretic Response to Intracarotid Infusions of Various Hypertonic Solutions in the Conscious GoatActa Physiologica Scandinavica, 1971
- A possible role of prostaglandin E2 in the regulation of vasopressin secretion in ratsLife Sciences, 1970
- Synergistic action of sodium and angiotensin on brain mechanisms controlling fluid balanceLife Sciences, 1970
- Evidence for a Hypothalamic Control of Renal Sodium ExcretionActa Physiologica Scandinavica, 1969
- Effect of Prostaglandin (PGEI) on the Permeability Response of Toad Bladder to Vasopressin, Theophylline and Adenosine 3′,5′-monophosphateNature, 1965
- Croonian Lecture - The antidiuretic hormone and the factors which determine its releaseProceedings of the Royal Society of London. B. Biological Sciences, 1947