Methyltetrahydrofolic Acid Mediates N - and O -Methylation of Biogenic Amines
- 5 October 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4107) , 74-75
- https://doi.org/10.1126/science.182.4107.74
Abstract
A variety of mammalian and avian tissues N - and O -methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S -adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O -methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.Keywords
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