Hereditary Degeneration of the Mouse Retina

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Abstract
In this hereditary retinal degeneration in the mouse, the retina develops normally for the first 14 days of life. Pyknotic cells then appear in the outer nuclear layer followed by thinning of that layer. The rods begin to lose their structure and by the 28th day they have disappeared. This is followed by patchy changes in the retinal pigment layer and choroid with irregular connective tissue formation between the retina and choroid. These later changes are probably purely secondary to the destruction of the rods. There is no development of cataract. The condition is inherited as a recessive Mendelian. character.
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