Assessment of palliative response in hyperthermia

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Abstract
It is important that clinical studies of hyperthermia will be able to define its contribution to palliative therapy. A variety of validated methods has been developed for assessing palliative therapy but none have been used in clinical studies of hyperthermia. In the present paper some of the methods available for the assessment of palliative therapy are reviewed. The necessary criteria for assessment of instruments for palliation, as well as the choice of method, is discussed. A simple strategy is proposed: use established methods and take advice on which to choose; selectively add relevant items, should this be necessary; use assessments made by patients as well as by clinicians; use the test instruments at least three times (before, during and after treatment), and pre-test it on a small series of patients before embarking upon a major study. It is hoped that, by drawing attention to the availability of such methods for evaluating palliation, they might prove important in more accurately evaluating the role of hyperthermia in the palliative treatment of cancer.