Initiation and Progression of Caries-Like Lesions of Enamel: Effect of Periodic Treatment with Synthetic Saliva and Sodium Fluoride

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Abstract
The effect of periodic treatment with synthetic saliva and sodium fluoride on initiation and progression of caries-like lesions of enamel using a single-section technique and polarized light microscopy was studied. The results indicated that periodic treatment with synthetic saliva and sodium fluoride rinses decreased the mean depth of the bodies of the lesion to a significant extent and reduced lesion formation rates during both the lesion initiation period and lesion progression period. Fluoride pretreatment followed by a 24-hour synthetic saliva rinse reduced the depth of lesion formation significantly when compared to synthetic saliva rinsing alone. The findings in this study imply that frequent application of relatively low concentrations of fluoride limits the progression of enamel caries to a significant extent.

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