JNK signaling in apoptosis
Top Cited Papers
Open Access
- 20 October 2008
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 27 (48) , 6245-6251
- https://doi.org/10.1038/onc.2008.301
Abstract
Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and antiapoptotic proteins through distinct phosphorylation events. This review analyses our present understanding of the role of JNK in apoptotic signaling and the various mechanisms by which JNK promotes apoptosis.Keywords
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