Asymmetric reduction of 7,8‐difluoro‐3‐methyl‐2H‐1,4‐benzoxazine. Synthesis of a key intermediate of (S)‐(‐)‐ofloxacin (DR‐3355)
- 1 February 1991
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 28 (2) , 329-331
- https://doi.org/10.1002/jhet.5570280222
Abstract
An efficient, highly enantioselective synthesis of (S)‐(‐)‐7,8‐difluoro‐2,3‐dihydro‐3‐methyl‐4H‐1,4‐benzoxazine, a key intermediate of (S)‐(‐)‐ofloxacin, using various chiral sodium triacyloxyborohydrides as reducing agents is reported.Keywords
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