Asymmetric reduction of 7,8‐difluoro‐3‐methyl‐2H‐1,4‐benzoxazine. Synthesis of a key intermediate of (S)‐(‐)‐ofloxacin (DR‐3355)

Abstract
An efficient, highly enantioselective synthesis of (S)‐(‐)‐7,8‐difluoro‐2,3‐dihydro‐3‐methyl‐4H‐1,4‐benzoxazine, a key intermediate of (S)‐(‐)‐ofloxacin, using various chiral sodium triacyloxyborohydrides as reducing agents is reported.

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