Involvement of the brain type of ryanodine receptor in T‐cell proliferation
Open Access
- 26 September 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 352 (2) , 206-210
- https://doi.org/10.1016/0014-5793(94)00955-4
Abstract
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T‐lymphocyte cells. Fura‐2 measurements revealed that the RYR in T‐cells functions as a ryanodine‐sensitive, caffeine‐insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T‐cells when added together with FK506.Keywords
This publication has 32 references indexed in Scilit:
- Cyclic ADP-Ribose in Insulin Secretion from Pancreatic βCellsScience, 1993
- Inositol trisphosphate and calcium signallingNature, 1993
- Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brainFEBS Letters, 1992
- Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal TransductionAnnual Review of Immunology, 1992
- Chemistry and Biology of the Immunophilins and Their Immunosuppressive LigandsScience, 1991
- Primary structure and functional expression from cDN A of the cardiac ryanodine receptor/calcium release channelFEBS Letters, 1990
- Patch Clamp Studies of Lymphocyte ActivationAnnual Review of Immunology, 1990
- Functional expression of the calcium release channel from skeletal muscle ryanodine receptor cDNAFEBS Letters, 1989
- Cellular Mechanisms Regulating [Ca2+]i Smooth MuscleAnnual Review of Physiology, 1989
- Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neuronsNeuron, 1988