Cation-Chloride Cotransporters in Neuronal Communication
- 1 December 2000
- journal article
- research article
- Published by American Physiological Society in Physiology
- Vol. 15 (6) , 309-312
- https://doi.org/10.1152/physiologyonline.2000.15.6.309
Abstract
Two isoforms of the cation-Cl– cotransporter family are expressed in neurons and modulate neurotransmission. NKCC1, a Na+-K+-2Cl– cotransporter, by raising internal Cl–, is responsible for excitatory GABAergic activity in immature brain and in adult sensory neurons. KCC2, a neuronal-specific isoform of the K+-Cl– cotransporter, by lowering internal Cl–, is critical for inhibitory GABA responses in mature central nervous system neurons.Keywords
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