INDUCTION OF MELANIN SYNTHESIS IN ALBINO MOUSE SKIN BY DNA FROM PIGMENTED MICE
- 1 September 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (1) , 184-189
- https://doi.org/10.1073/pnas.64.1.184
Abstract
Skin cells from albino mouse embryos have been shown to synthesize melanin after exposure to a nucleoprotein fraction of cells from pigmented mice. Although transformed clones were not found in any of 37 control experiments, at least 15 transformations took place in 10 of a series of 49 experiments using undegraded DNA. The active component in the transforming material appears to be DNA because DNase-treated preparations did not induce melanin synthesis.Keywords
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