Synthesis of [4,5-dehydroLeu2]- and [3,4-dehydropro6]-locust adipokinetic hormone
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 4,p. 723-729
- https://doi.org/10.1039/p19830000723
Abstract
The syntheses of [4,5-dehydroLeu2]- and [3,4-dehydroPro6]-locust adipokinetic hormone (LAKH) by the coupling of N-terminal hexapeptides prepared by the solid-phase method with a common C-terminal tetrapeptide synthesised in solution is described. At a dose level of 20 pmol, the former is at least as biologically active as LAKH, but the latter has only ca. 20% of the activity. Difficulties encountered in the incorporation of a 4,5-dehydroleucine residue into peptides are discussed.This publication has 10 references indexed in Scilit:
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