An Experimental Study of Dichloroethane Poisoning

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Abstract
Systemic administration of 1, 2-dichloroethane causes corneal clouding specifically in the dog, but its lethality is approximately equivalent in dogs, cats, rabbits, and rats. In contrast to the ocular effects on systemic administration, injection of dichloroethane into the anterior chamber is equally toxic to the corneas of dogs, cats, and rabbits. The characteristic abnormality resulting from acute exposure, however administered, is a necrosis of the corneal endothelium beginning in the basal portion of the cells, secondary swelling of the stroma, formation of excess basement membrane and thickening of Descemet's layer, and repair by sliding or stretching of the surviving endothelial cells.

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