Radioimmunoassay of Plasma Relaxin Levels Throughout Pregnancy and at Parturition in the Pig

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Abstract
Relaxin concentrations in peripheral plasma have been measured throughout pregnancy and immediately following parturition in the pig by radioimmunoassay. Gestation ranged from 114–117 days. Relaxin concentrations remained below 2 ng⁄ml during the first 100 days of pregnancy and then rose gradually to a mean of 11.9 ng⁄ml by 3 days before parturition. At this time, relaxin levels began to rise more rapidly and over the next 2 days increased to a mean concentration of 44.0 ng⁄ml by 30 h before parturition. Relaxin concentrations then increased sharply to a mean of 145.6 ng⁄ml by 14 h before parturition. This maximum was followed by a rapid decrease to a mean of 42.4 ng⁄ml by 2 h before parturition. At one day following parturition, relaxin levels were less than 1 ng⁄ml.(Endocrinology97: 834, 1975)

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