The Significance of the Philadelphia Chromosome in Acute Lymphoblastic Leukaemia: a Report of Two Cases
- 1 December 1977
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 37 (4) , 447-453
- https://doi.org/10.1111/j.1365-2141.1977.tb01017.x
Abstract
Two cases of Philadelphia chromosome (Ph1) positive acute lymphoblastic leukemia are reported, both of which lost the Philadelphia chromosome during remission. In one patient remission of the acute lymphoblastic leukemia continued but classical Ph1 positive chronic granulocytic leukemia developed. In the other patient relapse of the acute lymphoblastic leukaemia occurred associated with the return of the Ph1 chromosome. The chromosome aberration probably occurred in a pluripotential stem cell, which in 1 case proliferated along a lymphoid cell line and a myeloid cell line. Both cases responded well to conventional therapy for acute lymphoblastic leukemia.This publication has 9 references indexed in Scilit:
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