A COTTON PELLET GRANULOMA ASSAY FOR LOCALLY ADMINISTERED ANTI-INFLAMMATORY DRUGS: 9 HALO, 21 DESOXY-CORTICOIDS

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Abstract
MEIER, et at. (1), have demonstrated that foreign body granulomas are provoked in rats by subcutaneous implantation of cotton pellets and that administration of cortisone results in a diminution of granuloma formation. Shipley and Meyer (2) and others (3, 4) have developed assays for anti-inflammatory activity of systemically administered steroids which are based on these principles. Cotton granulomas also have been used to estimate circulating levels of endogenous anti-inflammatory substances during pregnancy and lactation (5, 6). Desaulles, et at. (7) and Stebbins and Stoerk (8) have studied the local effects of several substances in cotton granulomas by impregnating the cotton pellet with the test material before implantation. This cotton granuloma technique lends itself to the study of local steroid action because the same animal can bear both untreated and treated pellets, permitting a comparison.