Successful Treatment of Two Brothers with Congenital Afibrinogenemia for Splenic Rupture Using Heat- and Solvent Detergent-Treated Fibrinogen Concentrates

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Abstract
This report describes life-threatening spontaneous splenic rupture in two brothers with congenital afibrinogenemia. Patients: Two brothers, aged 11 and 14 years, had intra-abdominal bleeding due to splenic rupture confirmed by ECHO ultra-sonography and computed tomography scans. Results: Splenectomy was performed after administration of heat-and solvent-detergent treated fibrinogen concentrates. Conclusions: Hemostatic treatment for splenic rupture using heat- and solvent detergent-treated fibrinogen concentrates was effective. Careful attention must be paid to the risk of splenic rupture during the growth spurt in physically active children with this rare coagulation disorder.

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