A New Approach to β- and γ-Amino Esters and Amino Aldehydes by Regioselective Ozonolysis of 2,3-Dihydropyrroles and 1,2,3,4-Tetrahydropyridines
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (08) , 675-677
- https://doi.org/10.1055/s-1994-22972
Abstract
Upon ozonolysis of 2,3-dihydropyrroles 1a-e and 1,2,3,4-tetrahydropyridines 1f-j, either β- and γ-amino esters or amino aldehydes may be obtained in high yields; the scope and limitations of this approach are discussed. Through utilization of this methodology, an effective synthesis of various 2-aminocyclopropanecarboxylic acid derivatives (β- and γ-analogs of ACC) has been achieved.Keywords
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