Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.

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Abstract
A new candidate hormone-designated peptide YY (PYY)-was isolated from extracts of porcine upper intestinal tissue by a novel chemical assay method. This peptide was detected in the extracts by the presence of its unusual COOH-terminal tyrosine amide structure. The peptic consists of a linear chain of 36 amino acids and its complete amino acid sequence is: Tyr-Pro-Ala-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Ser-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2. This peptide has a distinct sequence homology to the pancreatic polypeptide. PYY and the pancreatic polypeptide may together form a new peptide family. PYY strongly inhibits both secretin- and cholecystokinin-stimulated pancreatic secretion in the anesthetized cats.