Alteration of thrornboxane and prostacyclin levels in experimental spinal cord injury
- 1 July 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 35 (7) , 1003
- https://doi.org/10.1212/wnl.35.7.1003
Abstract
We measured levels of thromboxane B2 and 6-keto-PGF10 in rabbit spinal cord and cat CSF after impact injury to spinal cord. Rabbit tiissue thromboxane B2 levels increased more than 6-keto-PGF10. In cat, CSF thromboxane B, was higher the first hour postinjury; CSF 6-keto-PGF10 also increased, but less so. These results imply activation of arachidonic acid metabolism. The relatively greater increase of thromboxane B, suggests that thromboxane-prostacyclin imbalance may contribute to post-traumatic ischemia.This publication has 22 references indexed in Scilit:
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